As of today, Geron has nine cell lines. Most of our development work has so far focused on three of these lines (details below). Five of them were derived at the University of Wisconsin-Madison, two are clones of one of the Wisconsin lines and two were derived at the University of California-San Francisco.
Geron funded the research by Dr. James Thomson of the University of Wisconsin-Madison in which Dr. Thomson first derived human embryonic stem cells. Geron has a license from the Wisconsin Alumni Research Foundation (WARF) which grants Geron exclusive commercialization rights to three cell types (cardiomyocytes, neural cells and pancreatic islet cells) and non-exclusive rights to three other cell types (hematopoietic cells, osteoblasts and chondrocytes) for therapeutic and diagnostic products; and non-exclusive rights to commercialize research products based on six cell types. Pursuant to Geron's agreement with WARF, Geron may transfer the undifferentiated cell lines only to Geron collaborators for work on projects described and directed by Geron.
Geron is committed to the rapid advancement of embryonic stem cell technology, and expects to collaborate with researchers at universities, companies, and other organizations in aggressively pursuing this important technology. We encourage parties interested in discussing possible collaborations to contact:
ES Request Geron Corporation 230 Constitution Drive Menlo Park, CA 94025 Email: esrequest@geron.com Tel: (650) 473-7216 Fax: (650) 463-7750
All other parties interested in obtaining embryonic stem cell lines are encouraged to contact WARF, through its subsidiary WiCell (www.wicell.org).
Stem Cell Line:
H1
Comments:
Cells were derived by J. Thomson at University of Wisconsin and are cell line WA01. Cells can be maintained feeder-free. Cells express OCT-4 and hTERT, give rise to teratomas containing derivatives of three germ layers in SCID mice, and differentiate in vitro into derivatives of all three germ layers.
Publication(s):
Thomson et al., (1998) Science 282: 1145. Xu et al., (2001) Nature Biotech. 19: 971. Carpenter et al., Exp. Neurol. 172: 383
Availability:
Pursuant to Geron's agreement with WARF, Geron may transfer this cell line only to Geron collaborators.
Stem Cell Line:
H7
Comments:
Cells were derived by J. Thomson at University of Wisconsin and are cell line WA07. Cells can be maintained feeder-free. Cells express OCT-4 and hTERT, give rise to teratomas containing derivatives of three germ layers in SCID mice, and differentiate in vitro into derivatives of all three germ layers.
Publication(s):
Thomson et al., (1998) Science 282: 1145.Xu et al., (2001) Nature Biotech. 19: 971. Carpenter et al., Exp. Neurol. 172: 383
Availability:
Pursuant to Geron's agreement with WARF, Geron may transfer this cell line only to Geron collaborators.
Stem Cell Line:
H9
Comments:
Cells were derived by J. Thomson at University of Wisconsin and are cell line WA09. Cells can be maintained feeder-free. Cells express OCT-4 and hTERT, give rise to teratomas containing derivatives of three germ layers in SCID mice, and differentiate in vitro into derivatives of all three germ layers. Cells can be cloned.
Publication(s):
Thomson et al., (1998) Science 282: 1145. Amit et al (2000) Dev. Biol. 227: 271. Xu et al., (2001) Nature Biotech. 19: 971. Carpenter et al., Exp. Neurol. 172: 383
Availability:
Pursuant to Geron's agreement with WARF, Geron may transfer this cell line only to Geron collaborators.
